The primary goal of this pilot project with Dr. Hai-Quan Mao (JHU Biomedical Engineering) is to develop an efficient biodegradable microparticle (BMP) system that provides sustained release of a malaria transmission-blocking AgAPN1 antigen, and then determine the efficacy of this BMP vaccine following a single dose oral immunization in generating high-titer, long-lasting antigen specific antibodies, compared with that elicited by intranasal and subcutaneous administrations of BMPs.