This research project is a randomized intervention study that is comparing two HIV/AIDS care program models and involves 300 HIV-infected women recruited from the Prevention of Mother-to-Child Transmission (PMTCT) program at Mulago Hospital, Kampala, Uganda. The study is evaluating compliance with anti-retroviral therapy (ARVs) recommendations by measuring drug adherence, regular clinic attendance at scheduled visits, and laboratory/clinical outcomes. The same standard of HIV/AIDS care is being provided to participants in both models including free access to ARVs, medical consultation, standard Ministry of Health approved laboratory monitoring tests, and most essential opportunistic infection medicines. All participants are also being encouraged to attend peer psychosocial support group meetings. However, the intervention model (1) is evaluating the effect of peer counselors and home visiting in combination with a greater emphasis on nurses for routine visits and longer intervals between scheduled visits. Whereas the standard clinic-based model (2) will promote adherence through routine counseling at each scheduled visit, care provided by a medical officer at each visit, and shorter intervals between visits. In addition, the use of cell/mobile phones will be assessed on the frequency and immediacy of provider-patient contact within both models, using a 2x2 factorial design. All participants will be followed for 12 months or until the end of the study period. The goal is to identify low-cost programmatic elements which directly affect optimal adherence to ARV therapy among women participating in a PMTCT program at this large public hospital in Uganda.