Initiative to establish international regional centers for the collection and harmonization of data and the establishment of an international research consortium to address unique and evolving research questions in HIV/AIDS currently unanswerable by single cohorts. More than 200,000 HIV-infected persons from 38 different countries are included. Questions regarding utilization and effectiveness of ARV therapy, toxicities, opportunistic disease and other co-morbidities (e.g., TB, hepatitis) and other topics will be addressed.

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