Assistant Scientist
M.D., Boston University School of Medicine, 1997, M.A., Carleton College, 1993
Bloomberg School of Public Health
International Health
Disease Control
- My research objectives are divided into three areas. The first is the epidemiology and impact of enteric infections on child health which continue to be among the principal cause of illness and death in children living in poverty. I also continue to be interested in the improvement of disease burden estimates in child health and a more balanced approach to research priority setting that is directed towards disease burden reduction. My final area of research area of interest is malaria epidemiology and more specifically the impact of economic influences and land use patterns on malaria in the Peruvian Amazon.
- diarrheal disease, disease burden, child health, Shigella, dysentery, nutrition, child health, Neotropical Anopholines, malaria, tropical medicine
Research Projects
Development and Testing of Human Brucellosis Diagnostics in an Endemic Country
Development and Testing of Human Brucellosis Diagnostics in an Endemic Country
Epidemiology of Shigellosis in teh Peruvian Amazon
The aim of this project is to determine dominant routes of transmission of shigellosis in a highly endemic setting by combining molecular typing of isolates obtained through the longitudinal surveillance of pediatric cohort and environmental sources.
Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development
The goal of the study is to describe the impact of repeated enteric infections on growth faltering, malnutrition and delayed child development. The primary hypothesis is that specific characteristics of the infections will impair gut integrity and lead to malnutrition. This is a cohort study to...
Human Reservoirs of Plasmodium Vivax Transmission in the Peruvian Amazon
The long-term goal of this project is to determine the specific epidemiological characteristics of P. vivax transmission in the Peruvian Amazon region towards the rational deployment of a transmission-blocking vaccine.
Road Construction, Colonization, and Epidemic Malaria in Peru’s Northern Amazon
Learn more about the project from the February 25, 2008, story on NPR, New Roads in the Amazon May Deliver Disease.
Between 2000 and 2004, Peru reported the largest net increase in malaria cases and the...
- Peer-reviewed Journal Articles
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1. Kosek M, Yori PP, Pan WK, Paredes Olortegui M, Gilman RH, Perez J, Banda Chavez C, Burga R, Hall E. Epidemiology of highly endemic multiply antibiotic resistant shigellosis in children in the Peruvian Amazon. Pediatrics, in press.
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2. Ramal Asayag C, Ruiz Garay C, Meza Sanchez G, Carey Angeles C, Jara Baca C, Evans C, Peñataro Yori P, Kosek M. Eight year old with fever, hepatomegaly, and positive thick smear. Am J Trop Med Hyg, in press.
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3. Matson R, Tong-Rios C, Banda Chavez C, Gilman RH, Florin D, Lopez-Sifuentes V, Cardenas Greffa R, Yori PP, Fernandez R, Velasquez Portocarrero D, Vinetz J, and Kosek M. Improved molecular technique for the differentiation of neotropical anopheline species. Am J Trop Med Hyg. 2008;78(3):492-8.
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4. Rudan I, Gibson J, Kapiriri L, Lansang MA, Hyder AA, Lawn J, Darmstadt GL, Cousens S, Bhutta ZA, Hess SY, Black M, Gardner JM, Webster J, Carneiro I, Chandramohan D, Kosek M, Lanata CF, Tomlinson M, Chopra M, Ameratunga S, Campbell H, El Arifeen S, Black RE: Child Health and Nutrition research Initiative (CHNRI). Setting priorities in global child health research investments: assessment of principles and practice. Croat Med J 2007;48(5):595-604.
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5. Bharti AR, Patra KP, Chuquiyauri R, Kosek M, Gilman R, Llanos-Cuentas A, Vinetz JM. Polymerase chain reaction detection of Plasmodium vivax and Plasmodium falciparum DNA from stored serum samples: implications for retrospective diagnosis of malaria. Am J Trop Med Hyg 2007;77(3):444-6.
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6. Verastegui M, Gilman RH, Arana Y, Barber D, Velasquez J, Farfan M., Chile N., Kosek J.C., Kosek M. Garcia H.H. and Gonzalez, A. T. solium oncosphere adhesion to intestinal epithelial and Chinese Hamster Ovary (CHO) cells in vitro. Infect.Immun 2007;75(11):5158-66.
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7. Leon-Barua R, Recavarren-Arce S, Chinga-Alayo E, Rodriguez-Ulloa C, Taylor DN, Gotuzzo E, Kosek M, Eza D, and Gilman RH. Helicobacter pylori-associated chronic atrophic gastritis involving the gastric body and severe disease by Vibrio cholerae. Trans R Soc Trop Med Hyg 2006; 100(6):567-572.
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8. Yori PP, Kosek M, Gilman RH, Cordova J, Bern C, Chavez CB et al. Seroepidemiology of strongyloidiasis in the Peruvian Amazon. Am J Trop Med Hyg 2006; 74(1):97-102.
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9. Finger SA, Velapatino B, Kosek M, Santivanez L, Dailidiene D, Quino W et al. Effectiveness of enterobacterial repetitive intergenic consensus PCR and random amplified polymorphic DNA fingerprinting for Helicobacter pylori strain differentiation. Appl Environ Microbiol 2006; 72(7):4713-4716.
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10. Bushen OY, Davenport JA, Lima AB, Piscitelli SC, Uzgiris AJ, Silva TM, Leite R, Kosek M, Dillingham RA, Girao A, Lima AA, Guerrant RL. Diarrhea and reduced levels of antiretroviral drugs: improvement with glutamine or alanyl-glutamine in a randomized controlled trial in northeast Brazil. Clin Infect Dis. 2004 Jun 15;38(12):1764-70.
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11. Kosek M, Bern C, Guerrant RL. The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000. Bull World Health Organ. 2003;81(3):197-204.
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12. Gilman RH, Anderton C, Kosek M, Garcia HH, Evans CA. How many committees does it take to make a project ethical? Lancet. 2002 Sep 28;360(9338):1025-6.
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13. Guerrant RL, Kosek M, Moore S, Lorntz B, Brantley R, Lima AA. Magnitude and impact of diarrheal diseases. Arch Med Res. 2002 Jul-Aug;33(4):351-5.
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14. Guerrant RL, Kosek M, Lima AA, Lorntz B, Guyatt HL. Updating the DALYs for diarrhoeal disease. Trends Parasitol. 2002 May;18(5):191-3.
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15. Kosek M, Alcantara C, Lima AA, Guerrant RL. Cryptosporidiosis: an update. Lancet Infect Dis. 2001 Nov;1(4):262-9.
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16. Kosek M, Lavarello R, Gilman RH, Delgado J, Maguina C, Verastegui M, Lescano AG, Mallqui V, Kosek JC, Recavarren S, Cabrera L. Natural history of infection with Bartonella bacilliformis in a nonendemic population. J Infect Dis. 2000 Sep;182(3):865-72.
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17. Mallqui V, Speelmon EC, Verastegui M, Maguina-Vargas C, Pinell-Salles P, Lavarello R, Delgado J, Kosek M, Romero S, Arana Y, Gilman RH. Sonicated diagnostic immunoblot for bartonellosis. Clin Diagn Lab Immunol. 2000 Jan;7(1):1-5.
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18. Kosek M, Lanata C, Black RE, Walker DG, Snyder JD, Abdus Salam M, Mahalanabis D, Fontaine O, Bhutta ZA, Bhatangar S, Rudan I. Directing diarrheal disease research towards disease burden reduction. Journal of Health, Population, and Nutrition, submitted.
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19. Fontaine O, Kosek M, Bhatnagar S, Boschi-Pinto C, Chan KY, Duggan C, Martinez Salgado H, Ribeiro H, Rollins NC, Salam MA, Shantosham M, Snyder JD, Tsai A, Vargas B, Rudan I. Setting research priorities to reduce global mortality form childhood diarrhoea by 2015. Lancet, submitted.
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Editorials
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1. Kosek M, Oberhelman RA. Unraveling the contradictions of vitamin A and infectious diseases in children. J.Infect.Dis. 2007;196(7):965-7.
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2. Guerrant RL, Kosek M. Polysaccharide conjugate typhoid vaccine. N Engl J Med. 2001 Apr 26;344(17):1322-3.
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Book Chapters
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Kosek, M and Black, RE
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E. coli
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Chapter for Maxcy-Rosenau-Last Public Health and Preventive Medicine, 15th ed. Ed. Robert Wallace, McGraw Hill, 2007.
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Kosek, M and Black, RE
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V. cholerae
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Chapter for Maxcy-Rosenau-Last Public Health and Preventive Medicine, 15th ed. Ed. Robert Wallace, McGraw Hill, 2007.
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Kosek M, Black RE, Keusch G
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Nutrition and Micronutrients in Tropical Infectious Diseases
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Chapter for Tropical Infectious Diseases: Principles, Pathogens, and Practice, 2nd ed. Ed. Richard L. Guerrant, Walker DH, and Weller PF. Elsevier Health Sciences, 2005.
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Kosek, M
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Traveler’s Diarrhea
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Teaching module for Physicians’ Information and Education Resource (PIER) an online publication series from the American College of Physicians, 2002.
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