Professor
Deputy Chair
PhD, University of Michigan, 1978; MA, University of Texas, 1974;
Bloomberg School of Public Health
Epidemiology
My research interest focus on the use of statistical genetics to identify genes contributing to risk of complex diseases, which includes most chronic diseases This work falls into the field of genetic epidemiology, and deals with diseases where both genes and environmental risk factors contribute to disease etiology. While I have worked on a wide variety of disease topics (pulmonary disease, diabetes, cancer), I have a long-standing interest in birth defects, particularly cleft lip and cleft palate. I have also recently developed a research interest in methods to detect genes controlling risk to infectious and parasitic diseases.
Epidemiology, Genetic epidemiology, Biostatistics, Oncology, statistical genetics, genetics of asthma and allergic diseases, birth defects, pulmonary diseases, host susceptibility to infectious diseases.
1971-1972 Texas Opportunity Plan Scholarship -
1972 Phi Beta Kappa -
1981 Outstanding Young Women of America (Maryland) -
1986 Delta Omega, Honorary Public Health Society
Research Projects
Center for Craniofacial Development and Disorders
The goal of the Center for Craniofacial Development and Disorders is to increase our understanding of normal and abnormal craniofacial development, promote prevention of craniofacial disease, and improve diagnosis and treatment of craniofacial disorders, including oral and dental conditions....
International Consortium to Identify Genes and Interactions Controlling Oral Clef
Oral clefts, which include cleft lip (CL), cleft lip and palate (CLP) and cleft palate (CP), and collectively represent one of the most common birth defects in humans. Oral clefts have a complex and heterogeneous etiology, with strong evidence for both genetic and environmental causal factors....
International Genetic Epidemiology of Oral Clefts
During the initial period of R01-DE-014581 (2003-2008), we successfully conducted a multi-center, international study on the genetic etiology of oral clefts (including cleft lip, CL; cleft lip and palate, CLP; and cleft palate, CP) by recruiting cases from 5 sites (Maryland, Singapore, Taiwan,...
Mapping And Susceptibility Genes For Nonsyndromic Oral Clefts In Western China
Oral clefts represent a major public health burden because of their high prevalence among newborns, the cost of surgical repair, and their continuing medical, psychological, and emotional burden to affected children and their families. While considerable progress has been made in recent years in...
Click here for a full listing of Dr. Beaty's PubMed citations -
Gao L, Grant AV, Rafaels N, Stockton-Porter M, Watkins T, Gao P, Chi P, Munoz M, Watson H, Dunston G, Togias A, Hansel N, Sevransky J, Maloney JP, Moss M, Shanholtz C, Brower R, Garcia JGN, Grigoryev DN, Cheadle C, Beaty TH, Mathias RA, Barnes KC. Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma. J ALLERGY CLIN IMMUNOL 119(5):1111-1118, 2007. PMID 17472811 -
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Jeronimo SMB, Holst AKB, Jamieson SE, Francis R, Martins DRA, Bezerra FL, Ettinger NA, Nascimento ET, Monteiro GR, Lacerda HG, Miller EN, Cordell HJ, Duggal P, Beaty TH, Blackwell JM, Wilson ME. Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection. GENES IMMUN 8(7):539-551, 2007. PMID 17713557 -
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*Park JW, Yun JE, Part T, Cho E, Jee SH, Jang Y, Beaty TH, Samet JM. Family history of diabetes and risk of atherosclerotic cardiovascular disease in Korean men and women. ATHEROSCLEROSIS 197:224-231, 2008. PMID 17493625 -
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Jeronimo SMB, Duggal P, Ettinger NA, Nascimento ET, Monteiro GR, Cabral AP, Pontes NN, Lacerda HG, Queiroz PV, Gomes CEM, Pearson RD, Blackwell JM, Beaty TH, Wilson ME. Genetic predisposition to self-curing infection with the protozoan Leishmania chagasi: A genomewide scan. J INFECT DIS 196:1261-1269, 2007. PMID 17955446 -
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*Chiu Y-F, Liang K-Y, Chuang L-M, Beaty TH. Incorporation of covariates into multipoint linkage disequilibrium mapping in case-control studies. GENET EPI 32:143-151, 2008. PMID 17968989 -
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*Sull JW, Liang, K-Y, Hetmanski JB, Fallin MD, Ingersoll RG, Park JW, Wu-Chou Y-H, Chen PK, Chong SS, Cheah F, Yeow V, Park BY, Jee SH, Jabs WE, Redett R, Jung E, Ruczinski I, Scott AF, Beaty TH. Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populations. GENET EPI 32:505-512, 2008. PMID 18357615 -
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*Sull JW, Liang K-Y, Hetmanski JB, Fallin MD, Ingersoll RG, Park JW, Wu-Chou Y-H, Chen PK, Chong SS, Cheah F, Yeow V, Park BY, Jee SH, Jabs WE, Redett R, Scott AF, Beaty TH. Excess maternal transmission of markers in TCOF1 among cleft palate case-parent trios from three populations. AM J MED GENET Part A 146A:2327-2331, 2008. PMID 18688869 -
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*Grant AV, Araujo MI, Ponte EV, Oliveira RR, Cruz AA, Barnes KC, Beaty TH. High heritability but uncertain mode of inheritance for total IgE level and Schistosoma mansoni infection intensity in a Schistosomiasis-Endemic Brazilian population. J INFECT DIS 198:1227-1236, 2008. PMID 18717640 -
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Rodríguez-Pla A, Beaty TH, Savino PJ, Eagle RC, Seo P, Soloski MJ. Association of a non-synonymous single nucleotide polymorphism of Matrix Metalloproteinase 9 with giant cell arteritis. ARTHRITIS & RHUMATISM 58:1849-1853, 2008. PMID 18512818 -
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Vergara C, Tsai YJ, Grant AV, Rafaels N, Gao L, Hand T, Stockton M, Campbell M, Mercado D, Faruque M, Dunston G, Beaty TH, Oliveira RR, Ponte EV, Cruz AA, Carvalho E, Araujo MI, Watson H, Schleimer RP, Caraballo L, Nickel RG, Mathias RA, Barnes KC. Gene encoding duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations. AM J RESPIR CRIT CARE MED 178:1017-1022, 2008. PMID 18827265 -
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Ettinger NA, Duggal P, Braz RFS, Nascimento ET, Beaty TH, Jeronimo SMB, Pearson RD, Blackwell JM, Moreno L, Wilson ME. Genetic admixture in Brazilians exposed to infection with Leishmania chagasi. ANN HUM GENET 73:304-313, 2009. PMID 19397557 -
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*Sull JW, Liang K-Y, Hetmanski JB, Fallin MD, Ingersoll RG, Park J, Wu-Chou Y-H, Chen PK, Chong SS, Cheah F, Yeow V, Park BY, Jee SH, Jabs EW, Redett R, Scott AF, Beaty TH. Maternal transmission effects of the PAX genes among cleft case-parent trios from four populations. EUR J HUM GENET 17:831-839, 2009. PMID 19142206 -
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Hansel NN, Gao L, Rafaels NM, Mathias RA, Neptune ER, Tankersley C, Grant AV, Connett J, Beaty TH, Wise RA, Barnes KC. Leptin receptor polymorphisms and lung function decline in chronic obstructive pulmonary disease. EUR RESPIR J 34:103-110, 2009. PMID 19196818 -
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Park BY, Sull JW, Park JY, Jee SH, Beaty TH. Differential parental transmission of markers in BCL3 among Korean cleft case-parent trios. J PREV MED PUB HLTH 42:1-4, 2009. PMID 19229118 -
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*Sull JW, Liang K-Y, Hetmanski JB, Wu T, Fallin MD, Ingersoll RG, Park JW, Wu-Chou Y-H, Chen PK, Chong SS, Cheah F, Yeow V, Park BY, Jee SH, Jabs EW, Redett R, Scott AF, Beaty TH. Evidence that TGFA influences risk to cleft lip with/without cleft palate through unconventional genetic mechansims. HUM GENET. 126:385-394, 2009. PMID 19444471 -
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Price AL, Tandon A, Patterson N, Barnes KC, Rafaels N, Ruczinski I, Beaty TH, Mathias R, Reich D, Myers S. Sensitive detection of chromosomal segments of distinct ancestry in admixed populations. PloS GENETICS 5:1-18, 2009. PMID 19543370 -
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Huang Y, Wu J, Ma J, Beaty TH, Sull JW, Zhu L, Lu D, Wong Y, Meng T, Shi B. Association between IRF6 SNPs and oral clefts in West China. J DENT RES 88:715-718, 2009. PMID 19734457 -
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Gao PS, Rafaels NM, Hand T, Murray T, Boguniewicz M, Hata T, Schneider L, Hanifin JM, Gallo RL, Gao L, Beaty TH, Beck LA, Barnes KC, Leung DYM. Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum. J ALLERGY CLIN IMMUNOL 124:507-513, 2009. PMID 19733298 -
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*Mathias RA, Grant AV, Rafaels N, Hand T, Gao L, Vergara C, Tsai YJ, Yang M, Campbell M, Foster C, Gao P, Togias A, Hansel N, Diette G, Adkinson NF, Liu M, Faruque M, Dunston GM, Watson H, Bracken MB, Hoh J, Maul P, Maul T, Murray T, Hetmanski JB, Ashworth R, Ongaco C, Hendricks K, Doheney K, Pugh E, Scott AF, Kabesch M, Liang L, Abecasis G, Moffatt MF, Cookson WOC, Ruczinski I, Beaty TH, Barnes KC. A genome-wide association study on African-ancestry populations identifies novel asthma genes. J ALLERGY CLIN IMMUNOL (Epub) 2009. PMID 19910028 -
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Hattori T, Konno S, Hizawa N, Isada A, Takahashi A, Shimizu K, Gao P, Beaty TH, Barnes KC, Huang SK, Nishimura M. Genetic variants in the mannose receptor gene (MRC1) are associated with asthma in two independent populations. IMMUNOGENETICS (Epub) 2009. PMID 19902202 -
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Sleiman PMA, Flory J, Imielinski M, Bradfield JP, Annaiah K, Willis-Owen SAG, Wang K, Rafaels NM, Michel S, Bonnelykke K, Zhang H, Kim CE, Frackelton EC, Glessner JT, Hou C, Otieno FG, Santa E, Thomas K, Smith RM, Glaberson WR, Garris M, Chiavacci RM, Beaty TH, Ruczinski I, Orange JM, Allen J, Spergel JM, Grundmeier R, Mathias RA, Christie JD, von Mutius E, Cookson WOC, Kabesch M, Moffatt MF, Grunstein MM, Barnes KC, Devoto M, Magnusson M, Li H, Grant SFA, Bisgaard H, Hakonarson H. Variants of DENND1B associated with asthma in children. NEJM (Epub) 2009. PMID 20032318 -
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* Dr. Beaty's student or trainee
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