Kathleen C. Barnes

Associate Professor
Director, Bayview Genetics Research Facility (BGRF) & The Lowe Family Genomics Core

Academic Degrees

B.S.N., Medical College of Virginia, VA Commonwealth Univ, 1984; PhD, Dept of Anthropology, The University of Florida, 1992

School/Organization
School of Medicine

Department / Division
Medicine
Allergy & Clinical Immunology

Joint Departmental Affiliations
Department of Epidemiology, Bloomberg School of Public Health; Division of Pulmonary & Critical Care Medicine

Center and Institute Affiliations
Other

Departmental Address
Johns Hopkins Asthma & Allergy Center
5501 Hopkins Bayview Circle, Rm 3A.62A

Email: kbarnes@jhmi.edu
Phone: 410-550-2071
Fax: 410-550-2130

Research and Professional Experience

• Dr. Barnes’ work focuses on the genetic basis for acute and chronic airway disease, and is based on diverse family-based and independent African Caribbean, South American, Western European (Netherlands, Germany), and local African American populations. Specifically, her studies are centered on gene-environment interactions and the interface of innate and adaptive immunity in the immunogenetics of various lung, allergic and infectious diseases including asthma, acute lung injury, atopic dermatitis and schistosomiasis.
• She is currently leading a genomics project and a genomics Core for the Specialized Centers of Clinically-Oriented Research (SCCOR) on ‘Molecular Approaches to Ventilator-Associated Lung Injury’ (Roy Brower, PI), and leads the genetics/genomics Core sections in two additional SCCORS, one focusing on pulmonary hypertension and the other on various rheumatic diseases. Additionally, she leads a genetics projects on two different Center grants on asthma, an NIH contract on vaccinia in atopic dermatitis, in addition to her own and other NIH-funded studies. She was recently awarded the Genome-Wide Association Studies to Identify Genetic Components that Relate to Heart, Lung and Blood Disorders, RFA HL-06-012, to perform a study on Genome-Wide Association Studies of Asthma in Populations of African Descent (R01 HL087699-01, Barnes, PI).

Honors and Awards

• 1982 - VA Fellowship, Women's Business Association of Danville
• 1988 - Vining Davis Field Research Award to conduct post-graduate fieldwork in the Dominican Republic
• 1988 - S.C. Johnson Research Travel Award to conduct post-graduate fieldwork in the Dominican Republic
• 1991 - Dow-Elanco Research Travel Award to conduct post-graduate fieldwork in Barbados
• 1992 - University of Florida Graduate Student Council Travel Award, 37th Annual Meeting of the Commonwealth Caribbean Medical Research Council; Curaçao, Netherlands Antilles
• 1994 - American Academy of Allergy and Immunology Travel Award, 50th Annual Meeting of the American Academy of Allergy & Immunology; Anaheim, California
• 1994 - Boehringer Research Travel Award, 39th Annual Meeting of the Commonwealth Caribbean Medical Research Council; Kingston, Jamaica
• 1994 - Glaxo Research Travel Award, 39th Annual Meeting of the Commonwealth Caribbean Medical Research Council Kingston, Jamaica
• 1995 - American Academy of Allergy and Immunology Travel Award, 51st Annual Meeting of the American Academy of Allergy & Immunology; New York
• 1996 - Maryland Chapter Research Grant ($10,616.00), Asthma and Allergy Foundation of America
• 1998, 1999 - New Investigator Award Grant ($20,000.00), Asthma and Allergy Foundation of America
• 2004 - Assembly on Allergy Immunology & Inflammation Travel Award, 100th Annual Meeting of the American Thoracic Society
• 2005 - Resequencing & Genotyping Service Application Award ($447,438), National Heart, Lung and Blood Institute
• 2007 - Margaret Ellen Nielsen Endowed Fellowship in Medical Genetics ($100,000), Terry W. Taylor, MD & Julia Frey Taylor, BSN

Research Projects
Candidate Genes in Dengue Hemorrhagic Fever
No abstract available

Prevalence of asthma and underlying risk factors in two Peruvian cities
Asthma was previously considered to be uncommon in Latin America; however, recent studies in different Latin American cities have identified that its prevalence currently ranges between 18% and 27%. These estimates are very high when compared with those reported in other developing countries and...



Selected Publications

• Gao L, Flores C, Ma SF, Miller EJ, Moitra J, Moreno L, Wadgaonkar R, Simon B, McVerry B, Brower R, Sevransky J, Tuder RM, Maloney JP, Moss M, Shanholtz C, Yates CR, Meduri GU, Ye SQ, Barnes KC, Garcia JGN. Macrophage migration inhibitory factor in acute lung injury: Expression, biomarker and associations. Translational Research 2007, In press.
• Williams MA, Cheadle C, Watkins T, Tailor A, Killedar S, Breysse P, Barnes KC, Georas SN. TLR2 and TLR4 as potential biomarkers of environmental particulate matter exposed human myeloid dendritic cells. Biomarker Insights 2007; 2: 225-39.
• Howell MD, Kim BE, Gao P, Grant AV, Boguniewicz M, DeBenedetto A, Schneider L, Beck LA, Barnes KC, Leung DYM. Cytokine modulation of atopic dermatitis filaggrin skin expression. J Allergy Clin Immunol. 2007 (epub ahead of print).
• Barnes KC, Grant AV, Hansel NN, Gao P, Dunston GM. African Americans with asthma. Proc. Am. Thoracic Soc. 2007; 4: 58-68.
• Gao L, Grant AV, Rafaels N, Stockton-Porter M, Watkins T, Gao P, Chi P, Munoz M, Watson H, Dunston G, Togias A, Hansel N, Sevransky J, Maloney JP, Moss M, Shanholtz C, Brower R, Garcia JGN, Grigoryev DN, Cheadle C, Beaty TH, Mathias RA, Barnes KC. Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma. J Allergy Clin Immunol. 2007; 119: 1111-8.
• Webb BT, van den Oord E, Akkari A, Wilton S, Ly T, Duff R, Barnes KC, Carlsen K, Gerritsen J, Lenney W, Silverman M, Sly P, Sundy J, Tsanakas J, von Berg A, Whyte M, Blumenthal M, Vestbo J, Middleton L, Helms PJ, Anderson WH, Pillai SG. Quantitative linkage genome scan for atopy in a large collection of Caucasian families. Hum Genet. 2007; 121: 83-92.
• Cheadle C, Becker KG, Cho-Chung YS, Nesterova M, Watkins T, Wood W III, Prabhu V, Barnes KC. A rapid method for microarray cross platform comparisons using gene expression signatures. Molecular & Cellular Probes 2007; 21: 35-46.
• Grigoryev DN, Liu M, Cheadle C, Barnes KC, Rabb H. Genomic profiling of kidney ischemia-reperfusion reveals expression of specific alloimmunity-associated genes: linking ‘immune’ and ‘nonimmune’ injury events. Transplantation Proceedings 2006; 38: 3333-6.
• Mathias RA, Gao P, Goldstein JL, Wilson AF, Pugh EW, Furbert-Harris P, Dunston GM, Malveaux FJ, Togias A, Barnes KC, Beaty TH, Huang SK. A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q. BMC Genetics 2006; 7: 38-48.
• Chi PB, Duggal P, Kao WHL, Mathias RA, Grant AV, Stockton ML, Garcia JGN, Ingersoll RG, Scott AF, Beaty TH, Barnes KC, Fallin MD. Comparison of SNP tagging methods using empirical data: Association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean population. Genetic Epidemiology. 2006; 30: 609-19.
• Barnes KC, Grant A, Gao P, Baltadjieva D, Berg T, Chi P, Zhang S, Zambelli-Weiner A, Ehrlich E, Zardkoohi O, Brummet ME, Stockton M, Watkins T, Gao L, Gittens M, Wills-Karp M, Cheadle C, Beck LA, Beaty TH, Becker KG, Garcia JGN, Mathias RA. Polymorphisms in the novel gene Acyloxyacyl Hydroxylase (AOAH) are associated with asthma and associated phenotypes. J. Allergy Clin. Immunol. 2006; 118: 70-7.
• Pillai SG, Chiano MN, White NJ, Barnes KC, Carlsen K, Gerritsen J, Helms P, Lenney W, Silverman M, Sly P, Sundy J, Tsanakas J, von Berg A, Whyte M, Speer M, Varsani S, Skelding P, Hauser M, Vance J, Pericak-Vance M, Burns DK, Middleton LT, Brewster SR, Anderson WH, Riley JH. A genome-wide search for linkage to asthma phenotypes in the Genetics of Asthma International Network families: Evidence for a major susceptibility locus on chromosome 2p. European J Human Genetics 2006; 14: 307-16.
• Barnes KC, Grant AV, Baltadzhieva D, Zhang S, Berg T, Shao L, Zambelli-Weiner A, Anderson W, Nelsen A, Pillai S, Yarnall DP, Dienger K, Ingersoll RG, Scott AF, Fallin MD, Mathias RA, Beaty TH, Garcia JGN, Wills-Karp M. Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families. Genes and Immunity. 2006; 7: 27-35.
• Blumenthal MN, Langefeld CD, Barnes KC, Ober C, Meyers DA, King RA, Beaty TH, Beck SR, Bleecker ER, Rich SS for the Collaborative Study on the Genetics of Asthma (CSGA). A genome-wide search for quantitative trait loci contributing to variation in pollen reactivity. J Allergy Clin Immunol. 2006; 117: 79-85.
• Lima JJ, Zhang S, Grant A, Shao L, Tantisira KG, Allayee H, Wang J, Sylvester J, Holbrook J, Wise R, Weiss ST, Barnes K. Influence of leukotriene pathway polymorphisms on response to montelukast in asthma. Am J Respir Crit Care Med. 2006; 173: 379-85.
• Gao L, Grant A, Halder I, Brower R, Sevransky J, Maloney JP, Moss M, Shanholtz C, Yates CR, Meduri GU, Shriver MD, Ingersoll R, Scott AF, Beaty TH, Moitra J, Ma SF, Ye SQ, Barnes KC, Garcia JGN. Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury. Am J Respir Cell Mol Biol. 2006; 34: 487-95.
• Barnes KC. Genetic epidemiology of health disparities in allergy and clinical immunology. J Allergy Clin Immunol. 2006; 117: 243-54.
• Sevransky J, Georas S, Barnes K. Single nucleotide polymorphisms in patients with sepsis and Acute Lung Injury. Contemporary Critical Care. 2006; 3: 1-8.
• Zambelli-Weiner A, Ehrlich E, Stockton ML, Grant AV, Zhang S, Levett PN, Beaty TH, Barnes KC. Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados asthma genetics study. J. Allergy Clin. Immunol. 2005; 115: 1203-9.
• Gao PS, Mathias RA, Plunkett B, Togias A, Barnes KC, Beaty TH, Huang SK. Genetic variants of the T-cell immunoglobulin mucin 1 (TIM-1), but not TIM-3, genes are associated with asthma in an African American population. J. Allergy Clin. Immunol. 2005; 115: 982-8.
• Mathias RA, Beaty TH, Bailey-Wilson JE, Bickel C, Stockton ML, Barnes KC. Inheritance of total serum IgE in the isolated Tangier Island population from Virginia: complexities associated with genealogical depth of pedigrees in segregation analyses. Human Heredity. 2005; 59: 228-38.

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