Assistant Professor
BSc, University of Toronto, 1988; MSc, University of Toronto, 1990; MDCM, McGill University, 1994; MPH, Johns Hopkins, 2002
School of Medicine
Medicine
Infectious Diseases
Dept. of Population and Family Health Sciences- JHSPH
- 2005 Performance Award - Division of Intramural Research, NIH/NIAID
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2005 Special Service Award - Division of Intramural Research, NIH/NIAID
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2001 Tuition Scholarship - JHSPH
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2000 McLaughlin Scholarship- McLaughlin Foundation of Canada (awarded to Canadian scientists seeking academis research training)
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1999 Travel Scholarship - Royal College of Physicians and Surgeons of Canada
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1994 Campbell Keenan Award (awarded to the member of the graduating class who, in the opinon of the Faculty, illustrates the greatest proficiency during General Surgery core training)
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1989 Ontario Graduate Scholarship
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1989 Multiple Sclerosis Society of Canada Studentship
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1984 Ontario Scholarship
Research Projects
A Randomized, controlled trial of Acyclovir prophylaxis versus placebo among HIV/HSV-2 co-infected individuals (through the Rakai Health Sciences Program)
Interventions that slow HIV-1 disease progression among persons with CD4+ counts above 250 cells/µL could postpone the need for antiretroviral therapy (ART) and prolong life-expectancy for HIV-infected persons. Herpes simplex virus type 2 (HSV-2) has been shown to up-regulate HIV-1 replication...
A randomized, controlled trial of short cycle intermittent versus continuous HAART for the treatment of chronic HIV infection in Uganda
Although highly active antiretroviral therapy (HAART) has been successful in suppressing plasma HIV RNA levels and providing significant clinical benefit in infected patients, it does not eradicate HIV infection. It is now clear that virus replication persists despite undetectable plasma viremia...
ARV effects on HIV epidemiology & behaviors, Rakai Uganda (through the Rakai Health Sciences Program)
The provision of HIV antiretroviral (ARV) therapy in Africa will have beneficial health and social effects, but will present many challenges. Since the drugs are now being initiated in Uganda, we have a narrow window of opportunity to assess the population-level impact of ARVs on HIV transmission...
Evaluation of a pilot cluster-randomized mobile phone intervention used by peer educators in a rural antiretroviral care program in Rakai, Uganda (through the Rakai Health Sciences Program)
To evaluate the feasibility of mobile phone technology used by peer educators as a strategy to facilitate communication and improve HIV care in a rural, resource-limited setting.
Fever in Ugandan Outpatients: A Microbiological Survey of Causative Organisms and Clinical Determinants (through the Rakai Health Sciences Program)
In malaria-endemic areas, fever is often assumed to stem from malaria. The objective of this study was to determine the microbiological causes of fever among HIV+ and HIV-Ugandans attending outpatient clinics.
Adult subjects attending rural outpatient clinics Nov 1 2006-April 11 2007 with...
Infectious Diseases Institute At Makerere University in Kampala Uganda
HIV Clinical Care, research and training in Uganda. Major research activities include ARV cohort, studies of IRIS, Kaposi''''s sarcoma, Neurologic complications of HIV, African clinical pharmacology, HIV resistance, and hepatitis B. Opportunities exist for training in the HIV Clinic directed by...
Natural history of chronic kidney disease in HIV-infected and HIV-seronegative individuals in Rakai, Uganda
In the US there is a striking racial disparity in the risk of end-stage renal disease among HIV-infected people: the incidence in blacks that is approximately 50-times higher than that in whites. However, little is known about the epidemiology and implications of kidney disease (KD) among HIV...
NIH/Johns Hopkins Bench to Bedside Project: Hepatitis B and HIV Co-Infection
The NIH Bench to Bedside program provides a unique opportunity to develop a systematic research program to improve understanding and management of HIV and hepatitis B (HBV) co-infection, from ‘bench’ to ‘bedside’ to ‘bush’. Building on the existing NIH/NIAID International Center for Excellence in...
SOLiD- Uganda
The Study of Liver Diseases in Uganda (SOLiD-Uganda) represents a consortium of investigators from Makere University, Mulago Hospital, the Rakai Health Sciences Program in Uganda and from Hopkins, NIAID, and UT-Southwestern in the US. Through a series of projects, our aim is to characterize the...
The Reach Out Mbuya HIV/AIDS Initiative
A growing number of studies have reported the experiences of antiretroviral therapy (ART) programs in the developing world. The majority of these studies report relatively short term outcomes (6 to 12 months) and most of these inaugural programs are embedded within research and academic settings....
Validation of algorithm for monitoring the virological efficacy of antiretroviral therapy in Africa
Routine virological monitoring of HIV-infected patients on antiretroviral therapy (ART) is not currently affordable or available in most African HIV clinics using standard methods such as RNA polymerase chain reaction (PCR). Alternative cheaper technologies to quantify the viral load are still...
Validation of filter paper methodology to perform HIV-1 PCR and HIV-1 genotyping for patients on HAART
Introduction and background information
Quantification of HIV RNA and the detection of genotypic resistance is usually performed on liquid plasma. The cost and technical requirements for a laboratory to offer this test are substantial. Therefore facilities to measure viral load are only...
Viral and immunologic factors contributing to the lack of HIV transmission among couples (through the Rakai Health Sciences Program)
Understanding the factors that contribute to the transmission of human immunodeficiency virus (HIV) infection is of great importance for the development of preventive and therapeutic strategies. Evidence suggests that a number of host immunologic and virologic factors play critical roles in...
- Twenty most recent publications:
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Gamiel JL, Tobian AA, Laeyendecker OL, Reynolds SJ, Morrow RA, Serwadda D, Gray RH, Quinn TC. Improved performance of enzyme-linked immunosorbent assays and the effect of human immunodeficiency virus coinfection on the serologic detection of herpes simplex virus type 2 in Rakai, Uganda. Clin Vaccine Immunol. 2008 May;15(5):888-90.
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Dutta S, Joglekar N, Joshi S, Reynolds SJ. Experience of conducting a phase I safety and acceptability trial of a candidate vaginal microbicide & lessons learned. Indian J Med Res. 2008 August; 128:212-3.
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Chang LW, Kagaayi J, Nakigozi G, Galiwango R, Mulamba J, Ludigo J, Ruwangula A, Gray RH, Quinn TC, Bollinger RC, Reynolds SJ. Telecommunications and Health Care: An HIV/AIDS Warmline for Communication and Consultation in Rakai, Uganda. J Int Assoc Physicians AIDS Care (Chic Ill). 2008 Sep;7(3):130-2.
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Shott JP, Iga B, Makumbi F, Luswata C, Kagulire C, Nammanda J, Mills LA, Serwadda D, Quinn TC, Reynolds SJ. CD4 Stabilization Tubes Maintain Accurate Absolute CD4 T-cell Counts for Six Days Compared to Standard K3 EDTA Tubes for Improved HIV Immunologic Monitoring in Resource-Poor Settings. CVI 2008 Oct; 15(10):1623-4.
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Kiragga A, Ocama P, Reynolds SJ, Kambugu A, Ojiambo H, Castelnuovo B. Validation of a portable hand-held lactate analyzer for determination of blood lactate in patients on antiretroviral therapy in Uganda. J Acquir Immune Defic Syndr. Dec 2008; 49(5): 564-5.
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Kagaayi J, Gray RH, Brahmbhatt H, Kigozi G, Nalugoda F, Wabwire-Mengen F, Serwadda D, Sewankambo N, Ddungu V, Ssebegala E, Sekassanvu J, Kigozi G, Makumbi G, Kiwanuka N, Lutalo T, Reynolds SJ, Wawer MJ. Survival of Infants Born to HIV-positive Mothers, by Feeding Modality, in Rakai, Uganda. Plos ONE. 2008 Dec; 3(12): e3877.
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Meya D, Spacek LA, Tibenderana H, John L, Namugga I, Magero S, Dewar R, Quinn TC, Colebunders R, Kambugu A, Reynolds SJ. Development and evaluation of a clinical algorithm to monitor patients on antiretrovirals in resource limited settings using adherence, clinical and CD4 lymphocyte count criteria. J Int AIDS Soc. 2009 Mar 4;12(1): 3.
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Reynolds SJ, Nakigozi G, Newell K, Ndyanabo A, Galiwongo R, Boaz I, Quinn TC, Gray R, Wawer M, Serwadda D. Failure of immunologic criteria to appropriately identify antiretroviral treatment failure in Uganda. AIDS. 2009 Mar 27;23(6):697-700.
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Chang LW, Alamo S, Guma S, Christopher J, Suntoke T, Omasete R, Montis JP, Quinn TC, Juncker M, Reynolds SJ. Two Year Virologic Outcomes of an Alternative AIDS Care Model: Evaluation of a Peer Health Worker and Nurse-Staffed Community-Based Program in Uganda. J Acquir Immune Defic Syndr. 2009 Mar 1;50(3):276-82..
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Tobian AR, Serwadda D, Quinn TC, Kigozi G, Gravitt PE, Laeyendecker O, Charvat B, Ssempijja V, Riedesel M, Oliver AE, Nowak RG, Moulton LH, Chen MZ, Reynolds SJ, Wawer MJ, Gray RH. Male Circumcision Prevents Herpes Simplex Virus type 2 (HSV-2) and Human Papillomavirus (HPV) Infections in HIV-Negative Men in Rakai, Uganda. N Engl J Med. 2009 Mar 26;360(13):1298-309.
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Suntoke T, Hardick A, Tobian AR, Mpoza B, Laeyendecker O, Serwadda D, Opendi P, Gaydos C, Gray RH, Wawer MJ, Quinn TC, Reynolds SJ. Evaluation of multiplex real-time PCR for detection of H. ducreyi, T. pallidum, HSV-1, and HSV-2 in the diagnosis of genital ulcer disease in Rakai District, Uganda. Sex Transm Infect. 2009 Apr;85(2):97-101.
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Redd AD, Dabitao D, Bream JH, Charvat B, Laeyendecker O, Kiwanuka N, Lutalo T Kigozi G Tobian AAR, Gamiel J, Neal JD, Oliver AE, Margolick JB, Sewankambo NS, Reynolds SJ, Wawer MG, Serwadda D, Gray RH, Quinn TC. Micorbial Translocation, the Innate Cytokine Response, and IHV-1 Diseases Progression in Africa. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6718-23.
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Cohee L, Mills LA, Kagaayi J, Jacobs I, Galiwango RM, Ludigo J, Ssekesanvu J, Reynolds SJ. High retention and appropriate use of insecticide-treated nets distributed to HIV-affected households in Rakai, Uganda: results from interviews and home visits. Malaria Journal 2009; Apr 22;8(1):76.
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Eshleman S, Laeyendecker O, Parkin N, Huang W, Chappey C, Paquet AC, Serwadda D, Reynolds SJ, Kiwanuka N, Quinn TD, Gray R, Wawer M. Antiretroviral drug susceptibility among drug naïve adults with recent HIV infection in Rakai, Uganda. AIDS 2009 Apr 27;27(7):845-52.
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Moore CC, Jacob ST, Pinkerton R, Banura P, Meya DB, Reynolds SJ, Kenya-Mugisha N, Mayanja-Kizza H, Scheld WM. Treatment of severe sepsis with artemether-lumefantrine is associated with decreased mortality in Ugandan patients without malaria. Am J Trop Med Hyg. 2009 May;80(5):723-8.
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Reynolds SJ, Kityo C, Mbamanya F, Dewar R, Ssali F, Quinn TC, Mugyenyi P, Dybul M. Evolution of drug resistance after virologic failure of a first highly active antiretroviral therapy regimen in Uganda. Antivir Ther. 2009;14(2):293-7.
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Wind-Rotolo M, Durand C, Cranmer L, Reid A, Martinson N, Doherty M, Jilek BL, Kagaayi J, Kiiza A, Pillay V, Laeyendecker O, Reynolds SJ, Eshleman S, Lau B, Ray SC, Siliciano JD, Quinn TC, Siliciano RF. Identification of nevirapine-resistant HIV-1 in the latent reservoir following single dose nevirapine to prevent mother-to-child transmission of HIV-1. J Infect Dis. 2009 May 1;199(9):1301-1309.
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Tobian AAR, Ssempijja V, Kigozi G, Oliver AE, Serwadda D, Makumbi F, Nalugoda FK, Boaz I, Reynolds SJ, Wawer MJ, Quinn TC, Gray RH. Incident HIV and Herpes Simplex Virus Type 2 Infection among Men in Rakai, Uganda. In Press AIDS 2009.
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Brankin E, Tobian AAR, Olaeyendecker O, Suntoke TR, Kizza A, Mpoza B, Kigozi G, Nalugoda F, Iga B, Chen M.C, Gray RH, Wawer MJ, Quinn TC, Reynolds SJ. Etiology of Genital Ulcer Disease in Female Partners of the Male Participants in a Circumcision Trial in Uganda. In Press. Int J STD AIDS 2009.
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Sendigaire H, Easterbrooke PJ, Arts E, Thomas D, Reynolds SJ. The challenge of HIV-1 antiretroviral resistance in Africa in the era of highly active antiretroviral therapy (HAART). A review. In Press. AIDS Reviews 2009.
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Tobian AR, Charvat C, Ssempijja V, Kigozi G, Serwadda D, Makumbi F, Iga B, Laeyendecker O, Riesdel M, Oliver A, Chen MZ, Reynolds SJ, Wawer MJ, Gray RH, Quinn TC. Factors Associated with the Prevalence and Incidence of Herpes Simplex Virus Type 2 Infections among Men in Rakai, Uganda. JID In press 2009.
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